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Article #123: Trileptal Side Effects

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Trileptal side effects including Stevens lung damage, arthritis, dry eye syndrome,
Johnson Syndrome (SJS) and Toxic and asthma. The potentially fatal
Epidermal Necrolysis (TEN) have been Trileptal side effect Toxic Epidermal
added to the drugs warning label Necrolysis has also been reported as a
following reports of an increased risk of reaction to the medication. TEN is
severe skin conditions in patients. similar to SJS in that it is a skin
Trileptal can cause allergic reactions disease that involves the development of
including skin reactions that in certain a rash that can spread throughout the
cases can be life-threatening. Trileptal body. TEN starts with non-specific
was approved by the Federal Drug symptoms that include cough, aching,
Administration (FDA) in January 2000. fever, and headaches. This can be
Trileptal, an anticonvulsant or followed by the development of a rash
antiepileptic drug (AED), was approved across the face and the torso of the body
for use as an adjunctive and monotherapy and then continue to spread to other
for the treatment of partial seizures in areas of the body. The rash can then lead
adults with epilepsy and for the to blisters which can form in areas such
adjunctive treatment of partial seizures as the eyes, mouth, and vaginal areas. In
in children, ages 4-16, with epilepsy. addition, the mucous membranes can be
The precise way that Trileptal affected. Toxic Epidermal Necrolysis can
(oxcarbazepine) exerts its antiseizure also cause layers of the skin to peel
effect is not fully understood. away in sheets. The affected skin can
Pharmacological activity results from resemble burned skin and cause serious
oxcarbazepine and its monohydroxy infections which can lead to death. A
metabolite (MHD). Oxcarbazepine and MHD reaction to medication is a significant
are known to block voltage-sensitive cause of both Stevens Johnson Syndrome
sodium channels, stabilizing hyper and Toxic Epidermal Necrolysis. Patients
excited neuronal membranes, inhibiting of any age can find themselves affected
repetitive firing, and diminution of the by these skin disorders. However, they
propagation of synaptic impulses. These are typically seen in older patients and
actions are thought to prevent the spread people with AIDS who have a diminished
of seizures. Oxcarbazepine and MHD also ability to fight off infections due to
appear to increase calcium conductance having a lower immunity. Patients who are
and modulate calcium channels in the experiencing any of the symptoms
central nervous system. The FDA reports a associated with Trileptal side effects
3 to 10 higher rate of Stevens Johnson should seek medical attention
Syndrome (SJS) and Toxic Epidermal immediately. The earlier that treatment
Necrolysis (TEN) than the average can be initiated the better chance there
incidence rates for these skin disorders. is for recovery.
Stevens Johnson Syndrome is a severe skin To learn more about Trileptal side
disease which is potentially effects please visit our website. We work
life-threatening. It may cause skin with Trileptal attorneys representing
peeling, rashes, blistering and sores on clients in Minnesota, Wisconsin, Iowa,
mucous membranes. SJS can lead to Arizona, North Dakota, South Dakota and
scarring of mucous membranes, blindness, throughout the United States.






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