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Article #160: Gadolinium MRI

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Gadolinium MRI and risk factors for the in the United States: Magnevist,
debilitating disease nephrogenic systemic MultiHance, Omniscan, OptiMARK, and
fibrosis (NSF) are currently being ProHance.
investigated by the Food and Drug Evidence has been increasing regarding
Administration (FDA). An MRI with the risk of nephrogenic systemic fibrosis
gadolinium is a type of MRI that uses a (NSF) in patients with severe kidney
contrast agent with special magnetic problems who receive gadolinium during an
properties to help increase the MRI procedure. Nephrogenic systemic
visibility of organs and tissues. Since fibrosis appears to occur in patients
its approval in 1988, MRI with gadolinium with kidney failure. Patients with kidney
has been administered to millions of disease or on kidney dialysis are at
patients. increased risk because gadolinium is
Magnetic resonance imaging (MRI) is a primarily eliminated by the body through
diagnostic study that has been used since the kidneys.
the 1980's. An MRI uses strong magnets Recent studies have shown an association
and radio waves to create computer between NSF and patients with kidney
generated three-dimensional images of the disease that have a gadolinium MRI.
body. When an MRI study is performed, Unfortunately, there has been little
radio waves are pulsed through the research or clinical trials that have
patient's body causing movement in studied patients with kidney problems and
hydrogen atoms in the body's cells. gadolinium contrast agents. NSF causes
Different parts of the body react to the fibrosis of the skin and connective
radio waves with predictable patterns. tissues throughout the body. The
These patterns are displayed as patient's skin thickens leading to a loss
three-dimensional pictures on a computer of mobility and in some cases causing
screen. death. There is no known treatment or
A gadolinium MRI is a special type of cure for NSF. NSF has only been reported
study where the patient is injected with in patients with severe renal dysfunction
gadolinium. For MRI studies using (kidney disease).
gadolinium the procedure usually involves The Food and Drug Administration (FDA)
two MRIs. The first MRI is administered has requested that the different
to get a baseline study. The second study manufacturers of gadolinium MRI contrast
involves injecting the patient with agent (GBCA) revise their product labels
gadolinium and then taking a second MRI. to include a new warning that describes
Gadolinium is a naturally occurring the increased risk of developing
metallic element that has special nephrogenic systemic fibrosis (NSF). The
magnetic properties. Gadolinium gives the FDA is continuing to review gadolinium
treating physician and radiologist a more for MRI as more studies and reviews
detailed picture of the patient's become available regarding the link
internal organs, tissues, bones and between gadolinium and NSF.
vessels. MRI with gadolinium is used Steve Fields
because it provides additional diagnostic To learn more about Gadolinium MRI please
information compared to an MRI without visit our website.
contrast. The Gadolinium for MRI agent is Our team of gadolinium lawyers represents
also referred to as gadolinium-based clients in Minnesota, Wisconsin, Iowa,
contrast agents (GBCA). Five GBCAs are Arizona, North Dakota, South Dakota and
approved for magnetic resonance imaging throughout the United States.






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